Lewis Hamilton remporte le Grand Prix du Brésil devant Max Verstappen et Valtteri Bottas. Sergio Perez termine 4e. On retrouve par la suite les Ferrari. Pierre Gasly termine 7e devant les deux Alpine. Lando Norris récolte le dernier point disponible.
| Pos | No | Pilote | Équipe | Tours | Temps | PTS |
|---|---|---|---|---|---|---|
| 1 | 44 | Lewis Hamilton | Mercedes | 71 | 1:32:22.851 | 25 |
| 2 | 33 | Max Verstappen | Red Bull Racing Honda | 71 | +10.496s | 18 |
| 3 | 77 | Valtteri Bottas | Mercedes | 71 | +13.576s | 15 |
| 4 | 11 | Sergio Perez | Red Bull Racing Honda | 71 | +39.940s | 13 |
| 5 | 16 | Charles Leclerc | Ferrari | 71 | +49.517s | 10 |
| 6 | 55 | Carlos Sainz | Ferrari | 71 | +51.820s | 8 |
| 7 | 10 | Pierre Gasly | AlphaTauri Honda | 70 | +1 lap | 6 |
| 8 | 31 | Esteban Ocon | Alpine Renault | 70 | +1 lap | 4 |
| 9 | 14 | Fernando Alonso | Alpine Renault | 70 | +1 lap | 2 |
| 10 | 4 | Lando Norris | McLaren Mercedes | 70 | +1 lap | 1 |
| 11 | 5 | Sebastian Vettel | Aston Martin Mercedes | 70 | +1 lap | 0 |
| 12 | 7 | Kimi Räikkönen | Alfa Romeo Racing Ferrari | 70 | +1 lap | 0 |
| 13 | 63 | George Russell | Williams Mercedes | 70 | +1 lap | 0 |
| 14 | 99 | Antonio Giovinazzi | Alfa Romeo Racing Ferrari | 70 | +1 lap | 0 |
| 15 | 22 | Yuki Tsunoda | AlphaTauri Honda | 70 | +1 lap | 0 |
| 16 | 6 | Nicholas Latifi | Williams Mercedes | 70 | +1 lap | 0 |
| 17 | 9 | Nikita Mazepin | Haas Ferrari | 69 | +2 laps | 0 |
| 18 | 47 | Mick Schumacher | Haas Ferrari | 69 | +2 laps | 0 |
| NC | 3 | Daniel Ricciardo | McLaren Mercedes | 49 | DNF | 0 |
| NC | 18 | Lance Stroll | Aston Martin Mercedes | 47 | DNF | 0 |
Meilleur tour: Sergio Perez