Sebastian Vettel (Red Bull) remporte le Grand Prix d’Espagne devant Lewis Hamilton (McLaren). Jenson Button (McLaren) monte sur la 3e marche du podium. Mark Webber (Red Bull) qui partait de la position de tête termine finalement 4e. Fernando Alonso (Ferrari) termine 5e. Michael Schumacher (Mercedes) termine devant son coéquipier Nico Rosberg. Sergio Perez et Kamui Kobayashi marquent tous les deux des points pour l’écurie Sauber.
| 1 | 1 | Sebastian Vettel | RBR-Renault | 66 | Winner | 2 | 25 |
| 2 | 3 | Lewis Hamilton | McLaren-Mercedes | 66 | +0.6 secs | 3 | 18 |
| 3 | 4 | Jenson Button | McLaren-Mercedes | 66 | +35.6 secs | 5 | 15 |
| 4 | 2 | Mark Webber | RBR-Renault | 66 | +47.9 secs | 1 | 12 |
| 5 | 5 | Fernando Alonso | Ferrari | 65 | +1 Lap | 4 | 10 |
| 6 | 7 | Michael Schumacher | Mercedes | 65 | +1 Lap | 10 | 8 |
| 7 | 8 | Nico Rosberg | Mercedes | 65 | +1 Lap | 7 | 6 |
| 8 | 9 | Nick Heidfeld | Renault | 65 | +1 Lap | 24 | 4 |
| 9 | 17 | Sergio Perez | Sauber-Ferrari | 65 | +1 Lap | 12 | 2 |
| 10 | 16 | Kamui Kobayashi | Sauber-Ferrari | 65 | +1 Lap | 14 | 1 |
| 11 | 10 | Vitaly Petrov | Renault | 65 | +1 Lap | 6 | |
| 12 | 15 | Paul di Resta | Force India-Mercedes | 65 | +1 Lap | 16 | |
| 13 | 14 | Adrian Sutil | Force India-Mercedes | 65 | +1 Lap | 17 | |
| 14 | 18 | Sebastien Buemi | STR-Ferrari | 65 | +1 Lap | 11 | |
| 15 | 12 | Pastor Maldonado | Williams-Cosworth | 65 | +1 Lap | 9 | |
| 16 | 19 | Jaime Alguersuari | STR-Ferrari | 64 | +2 Laps | 13 | |
| 17 | 11 | Rubens Barrichello | Williams-Cosworth | 64 | +2 Laps | 19 | |
| 18 | 21 | Jarno Trulli | Lotus-Renault | 64 | +2 Laps | 18 | |
| 19 | 24 | Timo Glock | Virgin-Cosworth | 63 | +3 Laps | 20 | |
| 20 | 25 | Jerome d’Ambrosio | Virgin-Cosworth | 62 | +4 Laps | 23 | |
| 21 | 22 | Narain Karthikeyan | HRT-Cosworth | 61 | +5 Laps | 22 | |
| Ret | 6 | Felipe Massa | Ferrari | 58 | +8 Laps | 8 | |
| Ret | 20 | Heikki Kovalainen | Lotus-Renault | 48 | Accident | 15 | |
| Ret | 23 | Vitantonio Liuzzi | HRT-Cosworth | 28 | +38 Laps | 21 |
Meilleur tour: Lewis Hamilton en 1:26.727 au 52e tour