Sebastian Vettel (Ferrari) a été le plus rapide de la 2e séance d’essais libres au Mexique. Lewis Hamilton (Mercedes) est 2e et Nico Rosberg (Mercedes) est 3e. Kimi Räikkönen (Ferrari) a fait le 4e temps. On retrouve ensuite Daniel Ricciardo (Red Bull), Nico Hulkenberg (Force India) et Max Verstappen (Red Bull).
| Pos | Pilote | Temps | Écart | Tours |
|---|---|---|---|---|
| 1 | 1:19.790 | 47 | ||
| 2 | 1:19.794 | +0.004s | 37 | |
| 3 | 1:20.225 | +0.435s | 46 | |
| 4 | 1:20.259 | +0.469s | 37 | |
| 5 | 1:20.448 | +0.658s | 43 | |
| 6 | 1:20.574 | +0.784s | 43 | |
| 7 | 1:20.619 | +0.829s | 42 | |
| 8 | 1:20.629 | +0.839s | 41 | |
| 9 | 1:20.974 | +1.184s | 46 | |
| 10 | 1:21.003 | +1.213s | 25 | |
| 11 | 1:21.193 | +1.403s | 39 | |
| 12 | 1:21.198 | +1.408s | 39 | |
| 13 | 1:21.326 | +1.536s | 45 | |
| 14 | 1:21.442 | +1.652s | 39 | |
| 15 | 1:21.579 | +1.789s | 41 | |
| 16 | 1:21.785 | +1.995s | 44 | |
| 17 | 1:21.980 | +2.190s | 42 | |
| 18 | 1:21.997 | +2.207s | 42 | |
| 19 | 1:22.037 | +2.247s | 43 | |
| 20 | 1:22.105 | +2.315s | 14 | |
| 21 | 1:22.298 | +2.508s | 44 | |
| 22 | 1:22.408 | +2.618s | 33 |