Carlos Sainz a terminé en tête de la première séance d’essais libres du Grand Prix du Mexique. Charles Leclerc est 2e. On retrouve ensuite les Red Bull et Lewis Hamilton. Fernando Alonso est 6e devant Valtteri Bottas et Lando Norris. Pierre Gasly et Sebastian Vettel sont du top 10.
| Pos | No | Pilote | Équipe | Temps | Écart | Tours |
|---|---|---|---|---|---|---|
| 1 | 55 | Carlos Sainz | Ferrari | 1:20.707 | 25 | |
| 2 | 16 | Charles Leclerc | Ferrari | 1:20.753 | +0.046s | 20 |
| 3 | 11 | Sergio Perez | Red Bull Racing RBPT | 1:20.827 | +0.120s | 22 |
| 4 | 1 | Max Verstappen | Red Bull Racing RBPT | 1:20.827 | +0.120s | 22 |
| 5 | 44 | Lewis Hamilton | Mercedes | 1:20.849 | +0.142s | 17 |
| 6 | 14 | Fernando Alonso | Alpine Renault | 1:20.899 | +0.192s | 26 |
| 7 | 77 | Valtteri Bottas | Alfa Romeo Ferrari | 1:21.083 | +0.376s | 23 |
| 8 | 4 | Lando Norris | McLaren Mercedes | 1:21.120 | +0.413s | 21 |
| 9 | 10 | Pierre Gasly | AlphaTauri RBPT | 1:21.310 | +0.603s | 25 |
| 10 | 5 | Sebastian Vettel | Aston Martin Aramco Mercedes | 1:21.525 | +0.818s | 24 |
| 11 | 3 | Daniel Ricciardo | McLaren Mercedes | 1:21.762 | +1.055s | 16 |
| 12 | 24 | Zhou Guanyu | Alfa Romeo Ferrari | 1:21.820 | +1.113s | 20 |
| 13 | 18 | Lance Stroll | Aston Martin Aramco Mercedes | 1:21.865 | +1.158s | 24 |
| 14 | 47 | Mick Schumacher | Haas Ferrari | 1:21.952 | +1.245s | 22 |
| 15 | 6 | Nicholas Latifi | Williams Mercedes | 1:22.912 | +2.205s | 20 |
| 16 | 40 | Liam Lawson | AlphaTauri RBPT | 1:23.861 | +3.154s | 19 |
| 17 | 45 | Logan Sargeant | Williams Mercedes | 1:24.246 | +3.539s | 22 |
| 18 | 19 | Nyck De Vries | Mercedes | 1:24.582 | +3.875s | 20 |
| 19 | 82 | Jack Doohan | Alpine Renault | 1:24.615 | +3.908s | 13 |
| 20 | 51 | Pietro Fittipaldi | Haas Ferrari | 1:26.766 | +6.059s | 9 |