Lewis Hamilton a été le plus rapide de la première séance d’essais libres au Mexique. Charles Leclerc est 2e. On retrouve ensuite les Red Bull, Valtteri Bottas et Sebastian Vettel. Carlos Sainz, les Toro Rosso et Antonio Giavinazzi sont également du top 10.
| Pos | No | Pilote | Équipe | Temps | Écart | Tours |
|---|---|---|---|---|---|---|
| 1 | 44 | Lewis Hamilton | Mercedes | 1:17.327 | 25 | |
| 2 | 16 | Charles Leclerc | Ferrari | 1:17.446 | +0.119s | 23 |
| 3 | 33 | Max Verstappen | Red Bull Racing Honda | 1:17.461 | +0.134s | 17 |
| 4 | 23 | Alexander Albon | Red Bull Racing Honda | 1:17.949 | +0.622s | 21 |
| 5 | 77 | Valtteri Bottas | Mercedes | 1:18.005 | +0.678s | 25 |
| 6 | 5 | Sebastian Vettel | Ferrari | 1:18.218 | +0.891s | 20 |
| 7 | 55 | Carlos Sainz | McLaren Renault | 1:18.401 | +1.074s | 21 |
| 8 | 10 | Pierre Gasly | Scuderia Toro Rosso Honda | 1:18.593 | +1.266s | 23 |
| 9 | 26 | Daniil Kvyat | Scuderia Toro Rosso Honda | 1:18.835 | +1.508s | 27 |
| 10 | 99 | Antonio Giovinazzi | Alfa Romeo Racing Ferrari | 1:18.959 | +1.632s | 22 |
| 11 | 27 | Nico Hulkenberg | Renault | 1:19.011 | +1.684s | 22 |
| 12 | 20 | Kevin Magnussen | Haas Ferrari | 1:19.013 | +1.686s | 22 |
| 13 | 7 | Kimi Räikkönen | Alfa Romeo Racing Ferrari | 1:19.205 | +1.878s | 22 |
| 14 | 4 | Lando Norris | McLaren Renault | 1:19.299 | +1.972s | 23 |
| 15 | 3 | Daniel Ricciardo | Renault | 1:19.499 | +2.172s | 23 |
| 16 | 18 | Lance Stroll | Racing Point BWT Mercedes | 1:19.679 | +2.352s | 21 |
| 17 | 11 | Sergio Perez | Racing Point BWT Mercedes | 1:19.717 | +2.390s | 23 |
| 18 | 8 | Romain Grosjean | Haas Ferrari | 1:19.850 | +2.523s | 22 |
| 19 | 63 | George Russell | Williams Mercedes | 1:20.548 | +3.221s | 26 |
| 20 | 40 | Nicholas Latifi | Williams Mercedes | 1:21.566 | +4.239s | 30 |